comparative molecular field analysis

https://doi.org/10.1351/goldbook.CT06951
Comparative Molecular Field Analysis (CoMFA) is a 3D-QSAR method that uses statistical correlation techniques for the analysis of the quantitative relationship between the biological activity of a set of compounds with a special alignment, and their three-dimensional electronic and steric properties. Other properties, such as @HT06964@ and H-bonding, can also be incorporated into the analysis.
Source:
PAC, 1997, 69, 1137. (Glossary of terms used in computational drug design (IUPAC Recommendations 1997)) on page 1140 [Terms] [Paper]