Term: electrospray laser desorption ionization mass spectrometry
https://doi.org/10.1351/goldbook.09184

Definition:
Measurement method in which a mass spectrometer is used to measure the ratio of mass to charge quotient and the abundance of ionized entities emitted from a sample in air via ablation by a focused pulsed laser while simultaneously directing an electrospray jet through the desorbed plume to enhance sample ionization.

Notes:
1) The desorption mechanism is thermal.
2) Both positive and negative ions are observed.
3) With the addition of a matrix on the sample, this is termed matrix-assisted laser desorption electrospray ionization (MALDESI).
4) With the use of an infrared laser for ablation, this has sometimes been termed laser ablation electrospray ionization (LAESI).

Link: 

Source: PAC, 2020, 92, 1781. 'Glossary of methods and terms used in surface chemical analysis (IUPAC Recommendations 2020)' on page 1786 (https://doi.org/10.1515/pac-2019-0404)

Citation: 'electrospray laser desorption ionization mass spectrometry' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.09184

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