Term: apoenzyme https://doi.org/10.1351/goldbook.A00417 Definition: The protein part of an enzyme without the cofactor necessary for catalysis. The cofactor can be a metal ion, an organic molecule (coenzyme), or a combination of both. Related Terms: 1) catalysis (http://doi.org/10.1351/goldbook.C00874). 2) coenzyme (http://doi.org/10.1351/goldbook.C01126). Source: PAC, 1994, 66, 2587. 'Glossary of bioanalytical nomenclature - Part 1: General terminology, body fluids, enzymology, immunology (IUPAC Recommendations 1994)' on page 2593 (https://doi.org/10.1351/pac199466122587) Citation: 'apoenzyme' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.A00417 License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/) for individual terms. Disclaimer: The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using.