Term: cross-flow filtration https://doi.org/10.1351/goldbook.C01407 Definition: Method of operating a filtration device where retained fluid is circulated over the membrane (filter) surface thus preventing undue build-up of filtered material on membrane (filter). Related Terms: 1) filtration (http://doi.org/10.1351/goldbook.F02388). 2) membrane (http://doi.org/10.1351/goldbook.MT06878). 3) filter (http://doi.org/10.1351/goldbook.F02384). Source: PAC, 1992, 64, 143. 'Glossary for chemists of terms used in biotechnology (IUPAC Recommendations 1992)' on page 151 (https://doi.org/10.1351/pac199264010143) Citation: 'cross-flow filtration' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.C01407 License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/) for individual terms. Disclaimer: The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using.