Term: comparative molecular field analysis (CoMFA)
https://doi.org/10.1351/goldbook.CT06951

Definition:
Comparative Molecular Field Analysis (CoMFA) is a 3D-QSAR method that uses statistical correlation techniques for the analysis of the quantitative relationship between the biological activity of a set of compounds with a special alignment, and their three-dimensional electronic and steric properties. Other properties, such as hydrophobicity and H-bonding, can also be incorporated into the analysis.

Related Terms:
1) hydrophobicity (http://doi.org/10.1351/goldbook.HT06964).

Source: PAC, 1997, 69, 1137. 'Glossary of terms used in computational drug design (IUPAC Recommendations 1997)' on page 1140 (https://doi.org/10.1351/pac199769051137)

Citation: 'comparative molecular field analysis (CoMFA)' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.CT06951

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