Term: denaturation
https://doi.org/10.1351/goldbook.D01586

Definition:
The process of partial or total alteration of the native structure of a macromolecule resulting from the loss of tertiary or tertiary and secondary structure that is a consequence of the disruption of stabilizing weak bonds. Denaturation can occur when proteins and nucleic acids are subjected to elevated temperature or to extremes of pH, or to non-physiological concentrations of salt, organic solvents, urea or other chemical agents.

Related Terms:
1) secondary structure (http://doi.org/10.1351/goldbook.S05530).
2) proteins (http://doi.org/10.1351/goldbook.P04898).
3) salt (http://doi.org/10.1351/goldbook.S05447).
4) nucleic acids (http://doi.org/10.1351/goldbook.N04245).

Source: PAC, 1992, 64, 143. 'Glossary for chemists of terms used in biotechnology (IUPAC Recommendations 1992)' on page 151 (https://doi.org/10.1351/pac199264010143)

Citation: 'denaturation' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.D01586

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