Term: feed-back inhibition (end product inhibition)
https://doi.org/10.1351/goldbook.F02333

Definition:
A metabolic control mechanism in which the end product of a biochemical sequence is able to inhibit the activity of an early enzyme in the sequence, thereby controlling the metabolic flux through this pathway. As an example, isoleucine controls its own synthesis by inhibiting threonine deaminase; adenosine 5-triphosphate (ATP) and citrate control glycolysis by inhibiting phosphofructokinase.

Related Terms:
1) sequence (http://doi.org/10.1351/goldbook.ST06775).
2) enzyme (http://doi.org/10.1351/goldbook.E02159).

Source: PAC, 1992, 64, 143. 'Glossary for chemists of terms used in biotechnology (IUPAC Recommendations 1992)' on page 154 (https://doi.org/10.1351/pac199264010143)

Citation: 'feed-back inhibition (end product inhibition)' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.F02333

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