Term: general acid catalysis
https://doi.org/10.1351/goldbook.G02609

Definition:
The catalysis of a chemical reaction by a series of Brønsted acids (which may include the solvated hydrogen ion) so that the rate of the catalysed part of the reaction is given by ∑kHA.[HA] multiplied by some function of substrate concentrations. (The acids HA are unchanged by the overall reaction.) General catalysis by acids can be experimentally distinguished from specific catalysis by hydrogen cations (hydrons) by observation of the rate of reaction as a function of buffer concentration.

Related Terms:
1) catalytic coefficient (http://doi.org/10.1351/goldbook.C00885).
2) intramolecular catalysis (http://doi.org/10.1351/goldbook.I03131).
3) pseudo-catalysis (http://doi.org/10.1351/goldbook.P04924).
4) catalysis (http://doi.org/10.1351/goldbook.C00874).
5) brønsted acids (http://doi.org/10.1351/goldbook.B00744).
6) substrate (http://doi.org/10.1351/goldbook.S06082).
7) specific catalysis (http://doi.org/10.1351/goldbook.S05796).
8) hydrons (http://doi.org/10.1351/goldbook.H02904).
9) rate of reaction (http://doi.org/10.1351/goldbook.R05156).

Source: PAC, 1994, 66, 1077. 'Glossary of terms used in physical organic chemistry (IUPAC Recommendations 1994)' on page 1117 (https://doi.org/10.1351/pac199466051077)

Citation: 'general acid catalysis' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.G02609

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