Term: hybridoma
https://doi.org/10.1351/goldbook.H02875

Definition:
A hybrid cell line resulting from the fusion of a specific antibody-producing spleen cell (lymphocyte) with a myeloma cell, which has the growth characteristics of the myeloma component and the antibody-secreting characteristics of the lymphocyte, and will multiply to become a source of pure monoclonal antibody.

Related Terms:
1) cell line (http://doi.org/10.1351/goldbook.CT06816).
2) antibody (http://doi.org/10.1351/goldbook.A00384).
3) monoclonal antibody (http://doi.org/10.1351/goldbook.M04010).

Source: PAC, 1992, 64, 143. 'Glossary for chemists of terms used in biotechnology (IUPAC Recommendations 1992)' on page 156 (https://doi.org/10.1351/pac199264010143)

Citation: 'hybridoma' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.H02875

License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/) for individual terms.

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