A hybrid cell line resulting from the fusion of a specific antibody-producing spleen cell (lymphocyte) with a myeloma cell, which has the growth characteristics of the myeloma component and the antibody-secreting characteristics of the lymphocyte, and will multiply to become a source of pure monoclonal antibody.
PAC, 1992, 64, 143. 'Glossary for chemists of terms used in biotechnology (IUPAC Recommendations 1992)' on page 156 (https://doi.org/10.1351/pac199264010143)