Term: immobilization
https://doi.org/10.1351/goldbook.I02973

Definition:
The technique used for the physical or chemical fixation of cells, organelles, enzymes, or other proteins (e.g. monoclonal antibodies) onto a solid support, into a solid matrix or retained by a membrane, in order to increase their stability and make possible their repeated or continued use. The principle is also used for affinity chromatography.

Related Terms:
1) organelles (http://doi.org/10.1351/goldbook.O04324).
2) enzymes (http://doi.org/10.1351/goldbook.E02159).
3) monoclonal antibodies (http://doi.org/10.1351/goldbook.M04010).
4) affinity chromatography (http://doi.org/10.1351/goldbook.A00177).
5) proteins (http://doi.org/10.1351/goldbook.P04898).
6) membrane (http://doi.org/10.1351/goldbook.MT06878).

Source: PAC, 1992, 64, 143. 'Glossary for chemists of terms used in biotechnology (IUPAC Recommendations 1992)' on page 157 (https://doi.org/10.1351/pac199264010143)

Citation: 'immobilization' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.I02973

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