Term: interstitial fraction https://doi.org/10.1351/goldbook.I03120 Definition: The interstitial volume per unit volume of a packed column. Defined by: ɛI = VI/X where V I is the interstitial volume and X the column volume. Related Terms: 1) interstitial volume (<em>in gas chromatography</em>) (http://doi.org/10.1351/goldbook.I03122). 2) column volume (<em>in gas chromatography</em>) (<em>in chromatography</em>) (http://doi.org/10.1351/goldbook.C01183). Source: Orange Book, 2nd ed., p. 100 (https://media.iupac.org/publications/analytical_compendium/) Citation: 'interstitial fraction' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.I03120 License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/) for individual terms. Disclaimer: The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using.