Term: intramolecular catalysis
https://doi.org/10.1351/goldbook.I03131

Definition:
The acceleration of a chemical transformation at one site of a molecular entity through the involvement of another functional ('catalytic') group in the same molecular entity, without that group appearing to have undergone change in the reaction product. The use of the term should be restricted to cases for which analogous intermolecular catalysis by chemical species bearing that catalytic group is observable. intramolecular catalysis can be detected and expressed in quantitative form by a comparison of the reaction rate with that of a comparable model compound in which the catalytic group is absent, or by measurement of the effective molarity of the catalytic group.

Related Terms:
1) neighbouring group participation (http://doi.org/10.1351/goldbook.N04100).
2) acceleration (http://doi.org/10.1351/goldbook.A00051).
3) transformation (http://doi.org/10.1351/goldbook.T06446).
4) catalysis (http://doi.org/10.1351/goldbook.C00874).
5) intramolecular (http://doi.org/10.1351/goldbook.I03130).
6) molecular entity (http://doi.org/10.1351/goldbook.M03986).
7) functional ('catalytic') group (http://doi.org/10.1351/goldbook.F02555).
8) intermolecular (http://doi.org/10.1351/goldbook.I03098).
9) chemical species (http://doi.org/10.1351/goldbook.CT01038).
10) effective molarity (http://doi.org/10.1351/goldbook.E01896).

Source: PAC, 1994, 66, 1077. 'Glossary of terms used in physical organic chemistry (IUPAC Recommendations 1994)' on page 1126 (https://doi.org/10.1351/pac199466051077)

Citation: 'intramolecular catalysis' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.I03131

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