Metabolic formation of a highly toxic compound from one that is relatively non-toxic (bioactivation), often leading to death of affected cells. Synonymous with suicide metabolism.
Source:
PAC, 1993, 65, 2003. 'Glossary for chemists of terms used in toxicology (IUPAC Recommendations 1993)' on page 2063 (https://doi.org/10.1351/pac199365092003)