Term: maximum tolerable dose (MTD) https://doi.org/10.1351/goldbook.M03769 Definition: Highest amount of a substance that, when introduced into the body, does not kill test animals (denoted by LD0). Source: PAC, 1993, 65, 2003. 'Glossary for chemists of terms used in toxicology (IUPAC Recommendations 1993)' on page 2067 (https://doi.org/10.1351/pac199365092003) Citation: 'maximum tolerable dose (MTD)' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.M03769 License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/) for individual terms. Disclaimer: The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using.