Term: protection of a reactive group
https://doi.org/10.1351/goldbook.PT07148

Definition:
Temporary chemical transformation of a reactive group into a group that does not react under conditions where the non-protected group reacts.

Note: For example, trimethylsilylation is a typical @T06446@ used to protect reactive functional groups, such as hydroxy or amino groups, from their reaction with growing anionic species in @A00361@.

Related Terms:
1) transformation (http://doi.org/10.1351/goldbook.T06446).
2) anionic polymerization (http://doi.org/10.1351/goldbook.A00361).

Source: PAC, 2004, 76, 889. 'Definitions of terms relating to reactions of polymers and to functional polymeric materials (IUPAC Recommendations 2003)' on page 894 (https://doi.org/10.1351/pac200476040889)

Citation: 'protection of a reactive group' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.PT07148

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