Term: random coil https://doi.org/10.1351/goldbook.R05124 Definition: The complete set of spatial arrangements of a chain molecule with a large number of segments that randomly change mutual orientation with time, under conditions in which it is free from external constraints that would affect its conformation. If the solution of the chain molecules is not in a theta state, the segments change mutual orientation only approximately randomly. Synonymous with statistical coil. Related Terms: 1) conformation (http://doi.org/10.1351/goldbook.C01258). Source: Purple Book, 1st ed., p. 50 (http://old.iupac.org/publications/books/author/metanomski.html) Citation: 'random coil' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.R05124 License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/) for individual terms. Disclaimer: The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using.