Term: spectral interference https://doi.org/10.1351/goldbook.S05816 Definition: interference due to the incomplete isolation of the radiation emitted or absorbed by the analyte from other radiation detected by the instrument. Its occurrence may be established by comparing the measures of the analyte-free blank solution and the solvent blank. Related Terms: 1) interference (<em>in analysis</em>) (http://doi.org/10.1351/goldbook.I03089). 2) radiation (<em>in analysis</em>) (http://doi.org/10.1351/goldbook.R05048). Source: Orange Book, 2nd ed., p. 169 (https://media.iupac.org/publications/analytical_compendium/) Citation: 'spectral interference' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.S05816 License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/) for individual terms. Disclaimer: The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using.