Term: steric-approach control
https://doi.org/10.1351/goldbook.S05996

Definition:
Control of stereoselectivity of a reaction by steric hindrance towards attack of the reagent, which is directed to the less hindered face of the molecule. Partial bond making is strong enough at the transition state for steric control to take place. This suggests that the transition state should not be close to products.

Related Terms:
1) product development control (http://doi.org/10.1351/goldbook.P04863).
2) stereoselectivity (http://doi.org/10.1351/goldbook.S05991).
3) transition state (http://doi.org/10.1351/goldbook.T06468).
4) steric hindrance (http://doi.org/10.1351/goldbook.S06000).
5) reagent (http://doi.org/10.1351/goldbook.R05190).

Source: PAC, 1994, 66, 1077. 'Glossary of terms used in physical organic chemistry (IUPAC Recommendations 1994)' on page 1168 (https://doi.org/10.1351/pac199466051077)

Citation: 'steric-approach control' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.S05996

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