Term: transannular strain
https://doi.org/10.1351/goldbook.T06434

Definition:
In medium-sized ring compounds, the strain due to repulsive nonbonded interactions between substituents or hydrogen atoms attached to non-adjacent ring atoms.

Related Terms:
1) strain (http://doi.org/10.1351/goldbook.S06037).
2) nonbonded interactions (http://doi.org/10.1351/goldbook.N04183).

Source: PAC, 1996, 68, 2193. 'Basic terminology of stereochemistry (IUPAC Recommendations 1996)' on page 2221 (https://doi.org/10.1351/pac199668122193)

Citation: 'transannular strain' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.T06434

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