Metabolic formation of a highly toxic compound from one that is relatively non-toxic (bioactivation), often leading to death of affected cells. Synonymous with suicide metabolism.
Source: PAC, 1993, 65, 2003. (Glossary for chemists of terms used in toxicology (IUPAC Recommendations 1993)) on page 2063 [Terms] [Paper]
Cite as: IUPAC. Compendium of Chemical Terminology, 2nd ed. (the "Gold Book"). Compiled by A. D. McNaught and A. Wilkinson. Blackwell Scientific Publications, Oxford (1997). XML on-line corrected version: http://goldbook.iupac.org (2006-) created by M. Nic, J. Jirat, B. Kosata; updates compiled by A. Jenkins. ISBN 0-9678550-9-8. https://doi.org/10.1351/goldbook.