https://doi.org/10.1351/goldbook.C01325
Interaction between the
substrate
binding sites of an allosteric enzyme
. Binding of a substrate molecule to one binding site
changes the affinity of the binding sites on the other subunits (cf. allosteric enzyme
) to the substrate by induction of a conformation
change at the other binding sites. Cooperative enzymes
typically display a sigmoid (S-shaped) plot of the reaction rate against substrate concentration.