critical study 

https://doi.org/10.1351/goldbook.CT06820
Investigation yielding the no observed adverse effect level that is used by the USEPA as the basis of the reference dose.
Source:
PAC, 2004, 76, 1033. (Glossary of terms used in toxicokinetics (IUPAC Recommendations 2003)) on page 1038 [Terms] [Paper]