https://doi.org/10.1351/goldbook.I03142
A , i.e. the heavier substrate reacts more rapidly than the lighter one, as opposed to the more usual 'normal' . The
kinetic isotope effect
in which isotope effect
, in which isotope effect
will normally be 'normal' when the frequency differences between the isotopic transition states
are smaller than in the reactants. Conversely, an inverse isotope effect
can be taken as evidence for an increase in the corresponding force constants
on passing from the reactant to the transition states
.