maximum tolerated dose (MTD)

https://doi.org/10.1351/goldbook.M03771
High
dose
used in
chronic toxicity
testing that is expected on the basis of an adequate subchronic study to produce limited
toxicity
when administered for the duration of the test period. It should not induce: (a) overt
toxicity
, for example appreciable death of cells or organ dysfunction, or (b) toxic manifestations that are predicted materially to reduce the life span of the animals except as the result of neoplastic development or (c) 10% or greater retardation of body
weight
gain as compared with control animals. In some studies,
toxicity
that could interfere with a carcinogenic effect is specifically excluded from consideration.
Source:
PAC, 1993, 65, 2003. (Glossary for chemists of terms used in toxicology (IUPAC Recommendations 1993)) on page 2068 [Terms] [Paper]