nuclear Overhauser effect spectroscopy 

Synonym: nuclear Overhauser enhancement spectroscopy
Acronym: NOESY
https://doi.org/10.1351/goldbook.08387
Measurement method of nuclear magnetic resonance spectroscopy based on the nuclear Overhauser effect to observe nuclei that are close to each other in space.
Notes:
  1. NOESY is typically run as a homonuclear A1A221H experiment.
  2. A NOESY spectrum yields through space correlations via dipolar cross-relaxation.
  3. For small molecules, NOE may be observed between protons that are up to 0.4 nm apart, while the upper limit for large molecules is about 0.5 nm.
  4. NOESY also detects chemical and conformational exchange, when it is termed exchange spectroscopy (EXSY).
Source:
PAC, 2021, 93, 647. (Glossary of methods and terms used in analytical spectroscopy (IUPAC Recommendations 2019)) on page 698 [Terms] [Paper]
Citation: 'nuclear Overhauser effect spectroscopy' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.08387 RIS BibTex EndNote
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