saturation transfer difference spectroscopy 

Initialism: STD
https://doi.org/10.1351/goldbook.08410
Measurement method of nuclear magnetic resonance spectroscopy that allows detection of transient binding of small molecule ligands to macromolecular receptors.
Note:
Range of applicable dissociation constants is approximately 10−3 M to 10−8 M. The experiment relies on ligand-signal attenuation through spin diffusion saturation propagating from the macromolecule.
Source:
PAC, 2021, 93, 647. (Glossary of methods and terms used in analytical spectroscopy (IUPAC Recommendations 2019)) on page 703 [Terms] [Paper]
Citation: 'saturation transfer difference spectroscopy' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.08410 RIS BibTex EndNote
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