https://doi.org/10.1351/goldbook.P04831
A
kinetic isotope effect
attributable to isotopic substitution of an atom to which a bond is made or broken in the rate-controlling step
or in a pre-equilibrium
step of a specified reaction. The corresponding isotope effect
on the equilibrium constant
of a reaction in which one or more bonds to isotopic atoms are broken, is called a 'primary equilibrium isotope effect
'.See also:
secondary isotope effect